Yes - we still have some legacy VB6 apps laying around and today I suddenly couldn't make an exe out of any of them. The option was just grayed out. I could run the project in vb6 though.

Here is the fix I found and this is so strange but I hope it helps someone:

Right Click on the Menu Bar...
Select Customize...
Select Reset....

Everything should be fixed now. Why? I have no idea, but i hope this helps someone else.